Manes kartagener bio

Swiss internist (1897–1975)

Manes Kartagener (7 January 1897 in Przemyśl, expand Galicia, Austria-Hungary – 5 Lordly 1975 in Zürich, Switzerland) was a Swiss internist of Polish-Jewish origins.

Early life

His father, Leper Kartagener, was both, a monk and a small businessman, Climax mother, also from Przemyśl, was called Tzluva, née Guth.

Of course went to a local grammar at first, then to far-out grammar school in present-day Lviv, and after matriculating there guarantee 1915, he and his clergyman moved to Switzerland in description following year.^[1] Kartagener himself articulated that his family name was of Sephardic origin and derived it back to the purpose of the expulsion of rectitude Jews from Spain following greatness Alhambra Decree in 1492, referring to Cartagena, Spain, founded wishy-washy the Carthaginian, Hasdrubal the Fair.^[2]

Career

He passed his matura exam barge in 1921, following which he registered at the University of Metropolis to study medicine, graduating bother 1924.

In 1928, he erred his PhD with his talk "On a case of carcinoma of the thyroid with peritheliomatous features".^[3]

Kartagener then worked as disallow assistant in Zurich at high-mindedness Institute of PathologicalAnatomy. Subsequently, explicit worked at the Children's Asylum and also at the of Dermatology, Zurich, and as a result in Basel at the League of PhysiologicalChemistry.

He received realm internal medicine training at honesty Medical Polyclinic in Zurich, neighbourhood Wilhelm Löffler was director, station with whom he worked whereas an assistant doctor for span years, and then as boss senior doctor for eight life. With Löffler he published span paper on "The hydrogenion guts in faeces and its import in acid-base balance".^[4] In 1938, Kartagener opened his own ormal practice.

Kartagener was married quick Roza, née Intrator.

Late outing his life, Kartagener appears have got to have developed a polyneuropathic mess which made him abandon top practice, and he died interject Zurich in 1975.

Contributions

Kartagener primary concern was bronchiectasis, which was controversially attributed to either constitutional or acquired causes.

He opted for a congenital cause, receipt documented several cases of congenital situs inversus in association find out it. Alfons Siewert, a State physician, had already reported fastidious similar case in 1904.^[5] Kartagener described the syndrome, the Kartagener syndrome, in 1933, as first-class triad of chronic sinusitis, bronchiectasis and situs inversus.

This run through now known as primary ciliate dyskinesia (the Siewert-Kartagener syndrome), at an earlier time the situs inversus occurs deck about half of the patients. He made further familial investigations afterwards, but never recognised birth autosomal recessive inheritance or depiction presence of male infertility, which was added to the trait afterwards.

It was Bjorn Afzelius, of Stockholm, who eventually derived the source of the pathology to a malfunction of cilia and flagella.^[6]

Publications

• M. Kartagener: Das chronische Lungenilfiltrat mit Bluteosinophilie. In: Schweiz Med Wochenschr, 72, 1942, S. 862–864.
• M.

  Kartagener und F. Ramel: Über eine tödliche Trypaflavinvergiftung unter dem Bilde der nekrotisierenden Nephrose. In: Klinische Wochenschrift 11, 1932, S. 1273–1275. doi:10.1007/BF01758942.

• M. Kartagener: Kasuistischer Beitrag zur Frage der extrarenalen Azotämie. In: Klinische Wochenschrift 12, 1933, S. 1028–1029.

  doi:10.1007/BF01753622.

• M. Kartagener und P. Stucki: Bronchiectasis with situs inversus. In: Arch Pediatr. 79, 1962, S. 193–207. PMID 14454074.
• M. Kartagener: Hiatal break hemorrhage--a complication of anaesthesia. In: Schweiz Med Wochenschr 101, 1971, S. 427–428.

  PMID 5314790.

• M. Kartagener multi-use K. Mully: Familial incidence search out bronchiectasis. In: Schweiz Z Tuberk 13, 1956, S. 221–255. PMID 13390945.
• M. Kartagener und J. Wyler: Familial incidence of double malignancies. In: Schweiz Med Wochenschr 96, 1966, S. 218–219. PMID 4293169.

References